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교실소개

해부학교실은 의학 교육의 가장 기본이 되는 해부학교육 즉, 인체의 기본구조를 통한 임상의학의 기초적인 교육 및 연구를 시행하고 있습니다.

본 교실에서는 의예과 2학년생을 대상으로 해부학, 조직학, 발생학 그리고 본과 1학년생을 대상으로 유전학과 신경해부학을 강의하고 있으며, 의과대학 내 간호학과 및 작업치료학과의 해부학 관련 강의를 담당하고 있습니다.

해부학실습은 2006년에 증축 및 개보수 그리고 시설설비가 대폭 개선된 국내 최고 수준의 제생의세관(해부학 실습실, 납골실, 추모실 구비)에서 이루어지고 있으며 의과대학은 물론 치과대학, 한의과대학 및 유관학과들(약학과, 한약학과, 스포츠과학부, 뷰티디자인학부, 미술대학, 원광보건대학 유관학과들)의 골학, 근학, 및 시체실습 등의 해부학실습이 효율적으로 이루어지고 있습니다. 또한 임상교수들을 비롯한 수련의들에게 국내외 연수를 통하여 취득한 새로운 수술기법의 도입 시 시체를 이용한 숙달 기회를 제공하는 등 진료수준의 향상에도 기여하고 있습니다.

 

교실연혁

  • 1982년 07월    해부학교실 설립 및 정연태 교수 부임
  • 1983년 03월    박승택 교수 부임
  • 1987년 03월    김정중 교수 부임
  • 1989년 03월    최민규 교수 부임
  • 1997년 03월    오재민 교수 부임
  • 2009년 08월    정연태 교수 퇴임
  • 2012년 03월    곽한복 교수 부임
  • 2014년 02월    곽한복 교수 퇴임
  • 2014년 07월    김정중 교수 퇴임
  • 2015년 03월    양미영 교수 부임
  • 2015년 08월    박승택 교수 퇴임
  • 2017년 03월    원형선 교수 부임

 

 

연구분야 및 주요활동

 

      / 골격계 분자생물학 관련 연구/

  • Methyl gallate inhibits osteoclast formation and function by suppressing Akt and Btk-PLCg2-Ca2+ signaling and prevents lipopolysaccharide-induced bone loss. Int J Mol Sci. 2017 Mar7;18(3).
  • Ethanolic extract of Schizonepeta tenuifolia attenuates osteoclast formation and activation in vitro and protects against lipopolysaccharide-induced bone loss in vivo. BMC Complement Altern Med. 2016;16(1):301.
  • Dendrobium moniliforme exerts inhibitory effects on both receptor activator of nuclear factor kappa-B ligand-mediated osteoclast differentiation in vitro and lipopolysaccharide-induced bone erosion in vivo. Molecules. 2016;21(3):295.
  • Ebselen is a potential anti-osteoporosis agent by suppressing receptor activator of nuclear factor kappa-B ligand-induced osteoclast differentiation in vitro and lipopolysaccharide-induced inflammatory bone destruction in vivo. Int J Biol Sci. 2016;12(5):478-88.
  • Niclosamide suppresses RANKL-induced osteoclastogenesis and prevents LPS-induced bone loss. Biochem Biophys Res Commun. 2016;470(2):343-349.
  • Nicotinamide phosphoribosyltransferase inhibits receptor activator of nuclear factor-κB ligand-induced osteoclast differentiation in vitro. Mol Med Rep. 2017;15(2):784-792.
  • Protocatechuic acid attenuates osteoclastogenesis by downregulating JNK/c-Fos/NFATc1 signaling and prevents inflammatory bone loss in mice. Phytother Res. 2016;30(4):604-12.
  • Lysyl oxidase modudlates the osteoblast differentiation of primary mouse calvaria cells. Int J Mol Med. 2015;36(6):1664-70.
  • Stauntonia hexaphylla leaf methanol extract inhibits osteoclastogenesis and bone resorption activity via proteasome-mediated degradation of c-Fos protein and suppression of NFATc1 expression. BMC Complement Altern Med. 2015;15:280.
  • Overexpression of prohibitin-1 inhibits RANKL-induced activation of p38-Elk-1-SRE signaling axis blocking MKK6 activity. Biochem Biophys Res Commun. 2015;463(4):1028-33.
  • Massive elimination of multinucleated osteoclasts by eupatilin is due to dual inhibition of transcription and cytoskeletal rearrangement. Bone Rep. 2015;3:83-94.
  • Development of a novel frontal bone defect mouse model for evaluation of osteogenesis efficiency. J Biomed Mater Res A. 2015;103(12):3764-71.
  • WHI-131 promotes osteoblast differentiation and prevents osteoclast formation and resorption in mice. J Bone Miner Res. 2016;31(2):403-15.
  • CTRP3 acts as a negative regulator of osteoclastogenesis through AMPK-c-Fos-NFATc1 signaling in vitro and RANKL-induced calvarial bone destruction in vivo. Bone. 2015;79:242-51.
  • Harpagoside inhibits RANKL-induced osteoclastogenesis via Syk-Btk-PLCg2-Ca2+ signaling pathway and prevents inflammation-mediated bone loss. J Nat Prod. 2015;78(9):2167-74.
  • Evaluation of a novel technique for intraperitoneal injections in mice. Lab Anim (NY). 2015;44(11):440-4.
  • Ostericum koreanum extract reduces LPS-induced bone loss through inhibition of osteoclastogenesis. Am J Chin Med. 2015;43(3):495-512.
  • The inhibitory effect of Angelica tenuissima water extract on receptor activator of nuclear factor-kappa-B ligand-induced osteoclast differentiation and bone resorbing activity of mature osteoclasts. Am J Chin Med. 2015;43(4):715-29.
  • The inhibitory effects of Citrus unshiu Markovich on receptor activator of nuclear factor-kappa-B ligand-mediated osteoclast differentiation and function. Food Science and Biotechnology. 2015;24(5):1837-43.
  • Esculetin attenuates receptor activator of nuclear factor kappa-B ligand-mediated osteoclast differentiation through c-Fos/nuclear factor of activated T-cells c1 signaling pathway. Biochem Biophys Res Commun. 2015;461(2):334-41.
  • Progranulin and a five transmembrane domain-containing receptor-like gene are the key components in receptor activator of nuclear factor κB (RANK)-dependent formation of multinucleated osteoclasts. J Biol Chem. 2015;290(4):2042-52.
  • Mollugin from Rubea cordifolia suppresses receptor activator of nuclear factor-κB ligand-induced osteoclastogenesis and bone resorbing activity in vitro and prevents lipopolysaccharide-induced bone loss in vivo. Phytomedicine. 2015;22(1):27-35.
  • Purslane suppresses osteoclast differentiation and bone resorbing activity via inhibition of Akt/GSK3b-c-Fos-NFATc1 signaling in vitro and prevents lipopolysaccharide-induced bone loss in vivo. Biol Pharm Bull. 2015;38(1):66-74.
  • Ampelopsis brevipedunculata extract prevents bone loss by inhibiting osteoclastogenesis in vitro and in vivo. Molecules. 2014;19(11):18465-78.
  • Dual Effect of Chrysanthemum indicum extract to stimulate osteoblast differentiation and inhibit osteoclast formation and resorption in vitro. Evid Based Complement Alternat Med. 2014;2014:176049.
  • Aconitum pseudo-laeve var. erectum inhibits receptor activator of nuclear factor kappa-B ligand-induced osteoclastogenesis via the c-Fos/nuclear factor of activated T-cells, cytoplasmic 1 signaling pathway and prevents lipopolysaccharide-induced bone loss in mice. Molecules. 2014;19(8):11628-44.
  • Emodin regulates bone remodeling by inhibiting osteoclastogenesis and stimulating osteoblast formation. J Bone Miner Res. 2014;29(7):1541-53.
  • Oleanolic acid acetate inhibits osteoclast differentiation by downregulating PLCg2-Ca2+-NFATc1 signaling, and suppresses bone loss in mice. Bone. 2014;60:104-11.
  • Genipin inhibits RANKL-induced osteoclast differentiation through proteasome-mediated degradation of c-Fos protein and suppression of NF-κB activation. J Pharmacol Sci. 2014;124(3):344-53.
  • 9-hydroxy-6,7-dimethoxydalbergiquinol inhibits osteoclast differentiation through down-regulation of Akt, c-Fos and NFATc1. Int Immunopharmacol. 2014;20(1):213-20.
  • Parthenolide inhibits osteoclast differentiation and bone resorbing activity by down-regulation of NFATc1 induction and c-Fos stability, during RANKL-mediated osteoclastogenesis. BMB Rep. 2014;47(8):451-6.
  • Costunolide inhibits osteoclast differentiation by suppressing c-Fos transcriptional activity. Phytother Res. 2014;28(4):586-92.
  • CT imaging biomarker for evaluation of emodin as a potential drug on LPS-mediated osteoporosis mice. Acad Radiol. 2014;21(4):457-62.
  • 2(S)-2’-methoxykurarinone inhibits osteoclastogenesis and bone resorption through down-regulation of RANKL signaling. Biol Pharm Bull. 2014;37(2):255-61.
  • Chlorogenic acid inhibits of osteoclast differentiation and bone resorption by down-regulation of receptor activator of nuclear factor kappa-B ligand-induced nuclear factor of activated T cells c1 expression. Biol Pharm Bull. 2013;36(11):1779-86.
  • Effect of Cornus Officinalis on receptor activator of nuclear factor-kappaB ligand (RANKL)-induced osteoclast differentiation. J Bone Metab. 2012;19(2):121-7.
  • Effect of interferon-γ on the fusion of mononuclear osteoclasts into bone-resorbing osteoclasts. BMB Rep. 2012;45(5):281-6.
  • Glutaredoxin2 isoform b (Glrx2b) promotes RANKL-induced osteoclastogenesis through activation of the p38-MAPK signaling pathway. BMB Rep. 2012;45(3):171-6.
  • VapB as a regulator of osteoclastogenesis via modulation of PLCγ2-Ca(2+)-NFAT signaling. FEBS Lett. 2012;586(3):263-9.
  • Inhibitory regulation of osteoclast differentiation by interleukin-3 via regulation of c-Fos and Id protein expression. J Cell Physiol. 2012;227(5):1851-60.
  • Amorphigenin inhibits osteoclast differentiation by suppressing c-Fos and nuclear factor of activated T cells. Anat Cell Biol. 2010;43(4):310-6.
  • Inhibition of osteoclast differentiation and bone resorption by rotenone, through down-regulation of RANKL-induced c-Fos and NFATc1 expression. Bone. 2010;46(3):724-31.

   

      / 신경해부분자생물학 및 신경행동학 관련 연구 /

  • Changes in epigenetic markers, DNMT1 and HDAC1/2, in the adult mouse hippocampus after cranial irradiation. Neurosci Lett. 2017;657:113-119.
  • BDNF and GABAergic transmission in neurodegeneration: a mini-review. Neural Regen Res.
  • Effects of cancer therapy on hippocampus-related function. Neural Regen Res. 2015;10(10):1572-73.
  • Possible involvement of hippocampal immediate-early genes in contextual fear memory deficit induced by cranial irradiation. Neurobiol Learn Mem. 2016;131:19-29.
  • Voluntary running depreciates the requirement of Ca2+-stimulated cAMP signaling in synaptic potentiation and memory formation. Learn Mem. 2016;23(8):442-9.
  • Trimethyltin-induced hippocampal neurodegeneration: A mechanism-based review. Brain Res Bull. 2016;125:187-99.
  • Involvement of BDNF/ERK signaling in spontaneous recovery from trimethyltin-induced hippocampal neurotoxicity in mice. Brain Res Bull. 2016;121:48-58.
  • Developmental and degenerative modulation of GABAergic transmission in the mouse hippocampus. Int J Dev Neurosci. 2015;47(Pt.B):320-32.
  • Experience-dependent induction of hippocampal ΔFosB controls learning. J Neurosci. 2015;35(40):13773-83.
  • Cranial irradiation regulates CREB-BDNF signaling and variant BDNF transcript levels in the mouse hippocampus. Neurobiol Learn Mem. 2015;121:12-19.
  • Hippocampal dysfunctions caused by cranial irradiation: A review of the experimental evidence. Brain Behav Immun. 2015;45C:287-296.
  • Glial activation with concurrent upregulation of inflammatory mediators in trimethyltin-induced neurotoxicity in mice. Acta Histochem. 2014;116(8):1490-500.
  • Nestin expression and glial response in the hippocampus of mice after trimethyltin treatment. Acta Histochem. 2014;116(8):1276-88.
  • Developmental and degenerative modulation of brain-derived neurotrophic factor transcript variants in the mouse hippocampus. Int J Dev Neurosci. 2014; 38:68-73.
  • Hippocampal dysfunction during the chronic phase following a single exposure to cranial irradiation. Exp Neurol. 2014;254:134-144.
  • Hippocampal dysfunctions in tumor-bearing mice. Brain Behav Immun. 2014;36:147-155.
  • Possible role of the glycogen synthase kinase-3 signaling pathway in trimethyltin-induced hippocampal neurodegeneration in mice. PLOS ONE. 2013;8(8):e70356.
  • Neurotoxicity of cancer chemotherapy. Neural Regen Res. 2013 June;8(17):1606-1614.
  • Neurobiological toxicity of radiation to hippocampal cells. Histol Histopathol. 2013;28(3):301-310.
  • Evaluation of biological responses in rats experimentally exposed to crude oil. J Biomed Res. 2012;13(4):276-281.
  • Possible involvement of galectin-3 in microglial activation in the hippocampus with trimethyltin treatment. Neurochem Int. 2012;61(7):955-962.
  • Acute treatment of methotrexate induces hippocampal dysfunction in a mouse model of breast cancer. Brain Res Bull. 2012;89(1-2):50-56.
  • Temporal profiles of synaptic plasticity-related signals in adult mouse hippocampus with methotrexate treatment. Neural Regen Res. 2012;7(21):1651-1658.
  • Fast neutron irradiation deteriorates hippocampus-related memory ability in adult mice. J Vet Sci. 2012;13(1):1-6.
  • Comparison of the dose-response relationship of radiation-induced apoptosis in the hippocampal dentate gyrus and intestinal crypt of adult mice. Radiat Prot Dosimetry. 2012;148(4):492-497.
  • Detrimental effect of fast neutrons on cultured immature rat hippocampal cells: relative biological effectiveness of in vitro cell death indices. Radiat Res. 2011;176(3):303-310.
  • Cytotoxicity of gamma-ray in rat immature hippocampal neurons. J Vet Sci. 2011;12(3):203-207.
  • Neurotoxicity of methotrexate to hippocampal cells in vivo and in vitro. Biochem Pharmacol. 2011;82(1):72-80.
  • Differential patterns of nestin and glial fibrillary acidic protein expression in mouse hippocampus during postnatal development. J Vet Sci. 2011;12(1):1-6.
  • Toluene induces depression-like behaviors in adult mice. Toxicol Res. 2010;26(4):315-320.
  • Granulocyte-colony stimulating factor ameliorates irradiation-induced suppression of hippocampal neurogenesis in adult mice. Neurosci Lett. 2010;486(1):43-46.
  • Promotion of cAMP responsive element-binding protein activity ameliorates radiation-induced suppression of hippocampal neurogenesis in adult mice. Toxicol Res. 2010;26(3):177-183.
  • Dose-response and relative biological effectiveness of fast neutrons: induction of apoptosis and inhibition of neurogenesis in the hippocampus of adult mice. Int J Radiat Biol. 2010;86(6):476-85.
  • Cyclophosphamide impairs hippocampus-dependent learning and memory in adult mice: Possible involvement of hippocampal neurogenesis in chemotherapy-induced memory deficits. Neurobiol Learn Mem. 2010;93(4):487-94.
  • Gamma-ray susceptibility of immature and mature hippocampal cultured cells. J Vet Med Sci. 2010;72(5):605-9.
  • Amifostine ameliorates recognition memory defect in acute radiation syndrome caused by relatively low-dose of gamma radiation. J Vet Sci. 2010;11(1):81-3.
  • Toluene inhibits hippocampal neurogenesis in adult mice. Pharmacol Biochem Behav. 2010;94(4):588-94.

 

  

      / 맨눈해부학 및 임상해부학 관련 연구/

  • Zuckerkandl Tubercle of the Thyroid Gland: Correlations between Findings of Anatomic Dissections and CT Imaging. Am J Neuroradiol 2017;38(7):1416-1420.
  • Morphological variations of the deltoid ligament of the medial ankle. Clin Anat 2016;29(8):1059-1065.
  • Topographical relationships between the obturator nerve, artery, and vein in the lateral pelvic wall. Int Urogynecol J 2016;27(2):213-218.
  • Intermuscular aponeuroses between the flexor muscles of the forearm and their relationships with the ulnar nerve. 2016;38(10):1183-1189.
  • Morphological patterns and variations of the nasal septum components and their clinical implications. J Craniofac Surg 2016;27(8):2164-2167.
  • Zuckerkandl’s tubercle of the thyroid gland: Its location in the anatomical position, and comparative morphology of the same specimens before and after fixation. Clin Anat 2015;28(4):472-476.
  • The enigmatic subcostal muscle: Anatomical study with application to spine and chest pain syndromes and avoidance of confusion on imaging. Clin Anat 2015;28(8):1017-1021.
  • Distribution of the internal branch of the human accessory nerve. Anat Sci Int 2015;90(3):180-186.
  • A new morphological classification for the fibularis quartus muscle. Surg Radiol Anat 2015;37(1):27-32.
  • Separate muscle bundles of the flexor digitorum superficialis overlying the ulnar nerve. Folia Morphol (Warsz) 2015;74(4):434-438.
  • Morphological characteristics of the cranial root of the accessory nerve. Clin Anat. 2014;27(8):1167-1173.
  • Rare communication between the musculo-cutaneous and median nerves in the forearm: its clinical significance. Am J Phys Med Rehabil 2014;93(10):920-924.
  • Classification system for flexor digitorum accessorius longus muscle variants within the leg: Clinical correlations. Clin Anat 2014;27(7):1111-1116.
  • Posterior tibiotalar ligament: an anatomic study correlated with MRI. Clin Anat 2013;27(5):798-803.
  • Morphologic study of the interior transverse scapular ligament. Clin Anat 2013;27(5):707-711.
  • Variable composition of the internal and external branches of the accessory nerve. Clin Anat 2014;27(1):97-101.
  • The location and morphometry of the thyroid isthmus in adult Korean cadavers. Anat Sci Int 2013;88(4):212-216.
  • The inferior epigastric artery arising from the internal iliac artery via a common trunk with the obturator artery. Anat Cell Biol 2012;45(4):285-287.
  • Morphological study of the proximal boundary of the flexor retinaculum and of its constituent parts. J Hand Surg Eur Vol 2012;37(1):35-41.
  • Topographic relationship between the medial intermuscular septum and the ulnar nerve in the upper arm. J Neurosurg 2011;114(6):1534-1537.
  • Superior and middle thyroid arteries arising from the common carotid artery. Surg Radiol Anat 2011;33(7):645-647.
  • “Digit anatomy”: a new technique for learning anatomy using motor memory. Anat Sci Educ 2011;4(3):132-141.
  • Topographic variations of the optic chiasm and the foramen diaphragma sellae. Surg Radiol Anat 2010;32(7):653-657.
  • A split and conjoined median nerve in the forearm. Anat Sci Int 2010;85(2):115-117.

 

 

 

교육목표 및 담당과목

    교육목표

의학 교육의 가장 기본이 되는 해부학 교육, 즉 인체의 기본구조에 대한 기초적인 교육을 통하여 임상의학의 기초를 다지는데 있다.

    담당과목

    해부학 인체의 기본구조를 습득하고 각종 장기들 간의 상호관계를 이해한다.
    조직학 인체 장기들을 현미경적 수준에서 이해하고 병리학의 기초를 다진다.
    발생학 수정에서부터 출산까지의 인체 발생과정을 이해한다.
    신경해부학 신경계의 구조를 이해하고 임상신경학의 기초를 다진다.
    유전학 인류의 다양성과 유전현상의 원리, 그리고 유전성질환들에 대한 구별 능력과 발생 원인 및 기전들에 대하여 이해한다.

 

 

교실구성원

사 진 성명 연구분야 이메일 전화번호
최민규 교수

최민규 (Choi, Min kyu)

상세보기

  • 독성학
  • 골격계분자생물학
mkchoi@wku.ac.kr 063)850-6761
오재민 교수

오재민 (Oh, Jae min)

상세보기

  • 골격계분자생물학
jmoh@wku.ac.kr 063)850-6794
양미영

양미영 (Yang, Mi young)

  • 신경행동학
  • 신경분자생물학
yangm@wku.ac.kr 063)850-6758
원형선

원형선 (Won, Hyung-Sun)

  • 맨눈해부학
  • 임상해부학
hswon01@wku.ac.kr 063)850 -6976